Polynucleotides
Polynucleotides (PNs) are one of the most exciting developments in regenerative cosmetic medicine, offering a gentle yet highly effective way to improve skin quality, hydration, and structure.
What Are Polynucleotides?
Polynucleotides are purified DNA fragments—commonly derived from salmon—designed to stimulate the skin’s natural regeneration processes. Research shows that they can improve skin texture, reduce wrinkle depth, enhance elasticity, and support tissue healing.
Unlike dermal fillers, polynucleotides do not add volume. Instead, they encourage the skin to restore itself at a cellular level by activating fibroblasts, increasing collagen production, and improving hydration.
Benefits of Polynucleotides
- Improved Skin Hydration & Radiance
PNs bind water and boost hydration, helping soften fine lines and promote a youthful glow.
- Enhanced Collagen & Elastin Production
Polynucleotides stimulate fibroblast activity, supporting collagen, elastin and extracellular matrix repair for firmer, more resilient skin.
- Tissue Repair & Anti‑Inflammatory Effects
PNs promote healing, reduce inflammation, and improve skin integrity—making them ideal after procedures or for compromised skin.
- Natural‑Looking Results
Because the treatment enhances your own cellular activity rather than adding volume, results appear soft, subtle, and naturally refreshed.
Who Is Polynucleotide Treatment For?
- Fine lines and wrinkles
- Loss of elasticity
- Dull, dehydrated, or crepey skin
- Early signs of ageing
- Sun damage and oxidative stress
- Thin, fragile under‑eye skin and dark circles
- Acne Scarring
No skin test is required prior to treatment. A full medical history will be taken prior to treatment, and you will have an opportunity to discuss the treatment in full with your Cosmetic Medicine Practitioner. You will need to complete a consent form before treatment.
DURATION OF EFFECT
A typical course involves:
- 3–4 sessions
- Every 2–4 weeks, depending on the treatment area
- Maintenance every 6–12 months
Results are gradual and cumulative as collagen and cellular repair improve over time.
ADVERSE TREATMENT RESPONSES
The common injection related side effects are localized and transient, and may include one or more of the following responses:
- Swelling / redness / bruising / pain / tenderness / itching
Rare side effects can occur, and these include:
- Injection into a blood vessel. This may cause temporary skin discoloration and breakdown, blistering and scab formation which may result in a scar.
- Very small chance of granuloma formation, which may require excision.
Extremely rare side effects:
- Cases of blindness have resulted from injection – especially when injecting the nose and between the eyes.
CAUTIONS and CONTRAINDICATIONS
- Pregnancy or breastfeeding
- Active infection on the face
- Any dental work within 2 weeks of treatment
- Long haul flight within 7 – 10 days after treatment
- Covid Vaccination within 2 weeks of treatment
- If you have had Covid you must wait 2 weeks after receiving a negative test, before we are able to treat you for dermal filler
- Previous hypertrophic scarring – keloid
- Laser or deep chemical peels within 3 weeks of treatment
- Some rheumatological disorders
- Had botulinum toxin treatment to crow’s feet in last 4 weeks – please inform your Cosmetic Medicine Practitioner
AFTER CARE INSTRUCTIONS
Severe or increasing redness / pain / swelling must be reported to your Cosmetic Medicine Practitioner immediately.
DO’S AND DON’TS TO KEEP IN MIND FOR THE FIRST 24 HOURS AFTER TREATMENT
- You may use a gentle cold compress to soothe treated areas and to minimise swelling.
- TRY to keep the areas free from cosmetics – use only oil-free or water-based makeup
- RELAX and take it easy – you deserve it
- DO NOT expose your skin to prolonged sun
- DO NOT immerse yourself in a hot spa/sauna or engage in vigorous exercise/aerobics
- DO NOT DRINK ALCOHOL, especially red wine, for 24 hours as it may increase bruising
We hope you will be delighted with the outcome of your treatment. If for any reason you are concerned about the possibility of a serious adverse reaction, please phone Clinic 42 on (09) 638 4242
REJURAN® is a dermal tissue reconstructive material, animal-derived. REJURAN® is an injectable gel which is intended for injection into the mid to deep dermis to promote tissue restoration and reconstruction, and improvement of physical appearance. Administered by injecting the gel into the dermis using a thin gauge needle. The polynucleotide is hydrating to cause volumetric increases of tissues and make more favourable physiological conditions for the growth of cells in the skin. REJURAN® treatment is not funded on the New Zealand Pharmaceutical Schedule. You will need to pay for this medicine. Normal Doctors visit fees apply. REJURAN treatment should be administered only by trained medical professionals. Speak to your doctor about your own situation and about the benefits/risks of this procedure in appearance medicine. For further information, the Data Sheet and Consumer Medicines Information can be accessed at www.medsafe.govt.nz or ask your doctor. If you have any side effects or concerns speak to your doctor.
